The only long term effect that I know of is a decrease in the levels
of neurotransmitters in your nervous system. This is exactly what
leads to the end of weight loss with phentermine, as it just quits
working on your body.
Another long-term effect I've heard only a few people talking about
is hair falling out. After following along with weight loss surgery
group on Yahoo, I've learned that this happens if you lose weight
fast enough to be an unhealthy amount of loss every week.
This super-fast weight loss that some people achieve with Phentermine
causes their bodies to search for protein, and it sometimes eats
some hair..
If anyone has more information on this, or any corrections, then
please post about it! I have no problem with being wrong. 
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