The 37.5mg tabs are not time release. The time released ones are in gelcaps or have a coating to slowly release the meds. Since the 37.5's arent time released, I've had good results breaking them in half and doing half in the morning and half around mid-day, or half hour before lunch time...that way you feel like sleeping when the time comes. For me personally, anything that had a time released coating didnt work at all. Just a little note about time released pills, if you do have any, never break those in half, the dose inside is intended to slowly be delivered....with some meds, a cracked or compromised coating will send out "too much too fast" and depending on the meds, that can be a very bad thing. Well, I hope this helped you some. To answer your question is there a big difference between them.....to me, yes, a huge one. As to if you should wait before starting them, I'm not sure but I wouldnt think it would matter. To be on the safe side, I'd ask your doc. Take care.
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