I had been the 37.5s for over four months and after experiencing the pounding, migraine like headaches I took myself off of them. I want and need to lose this weight, but not being able to function throughout the day just wasn't working for me. I took Motrin as often as I could, but it didn't seem to help.
Also, I drink close to 100oz of water a day, so dehydration can't be the blame and since I've been off (3 weeks now), I haven't had another headache.
Good luck. I know how it feels.
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