Trishelle, The difference is, by breaking it in 1/2 and taking the first 1/2 in the morning, you are only putting into your system, roughly, 18.7 mg.s. The tablets aren't time released, so it works a lot better for some people when they first begin the phentermine. Taking the second 1/2 in early pm will give you approx. the same amount. Not everyone is able to tolerate the entire 37.5 mg at once in the beginning. dawg
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